AR-News: Surprising Breakthrough! Pregnant Monkeys Should Not Take Cocaine

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From: primfocus at waste.org
Neurotoxicol Teratol. 2004 Jan-Feb;26(1):13-21.  Links


Neurobehavioral deficits in neonatal rhesus monkeys exposed to cocaine in
utero.

He N, Bai J, Champoux M, Suomi SJ, Lidow MS.

Department of Biomedical Sciences, Neuroscience Division, University of
Maryland, Baltimore, 5-A-12, HHH, 666 W. Baltimore Street, Baltimore, MD
21201, USA.

In spite of significant efforts, the neurobehavioral deficits in infants
born from cocaine-abusing mothers have not been clearly defined. In the
present study, we examined the presence of these abnormalities in a rhesus
monkey model of prenatal cocaine exposure using a nonhuman primate
adaptation of the Neonatal Behavioral Assessment Scale (NBAS). Pregnant
monkeys (n=14) received 10 mg/kg cocaine twice a day orally (in fruit
treats) from the 40th through 102nd postconception days (PCD40-PCD102),
which is the period of cerebral cortical neuronogenesis ( approximately
second trimester). The control consisted of pregnant monkeys (n=14)
receiving fruit treats only. The animals were allowed to deliver vaginally
at term ( approximately PCD165). The first testing session was conducted on
PCD171 (within the first week after birth); the second testing session was
conducted on PCD177 (within the second week after birth); the third test was
conducted on PCD183 (within the third week after birth); and the fourth
testing session was conducted on PCD189 (within the fourth week after
birth). The prenatally cocaine-exposed infants showed deficits in
orientation, state control, and motor maturity, which were detectable during
the second, third, and fourth testing sessions. The same testing sessions
also revealed a significant reduction in the time devoted to toy
manipulation, which points to impaired attention. None of these
abnormalities were seen during the first testing session. The first session,
however, revealed increased tremulousness (one of the indicators of
autonomic stability) in the prenatally cocaine-exposed infants. This
impairment disappeared by the third testing session. The present findings
demonstrate the potential of prenatal cocaine exposure to induce
neurobehavioral deficits detectable by NBAS-like testing in primate infants.


Neurotoxicol Teratol. 2004 Jan-Feb;26(1):13-21.  Links


Neurobehavioral deficits in neonatal rhesus monkeys exposed to cocaine in
utero.

He N, Bai J, Champoux M, Suomi SJ, Lidow MS.

Department of Biomedical Sciences, Neuroscience Division, University of
Maryland, Baltimore, 5-A-12, HHH, 666 W. Baltimore Street, Baltimore, MD
21201, USA.

In spite of significant efforts, the neurobehavioral deficits in infants
born from cocaine-abusing mothers have not been clearly defined. In the
present study, we examined the presence of these abnormalities in a rhesus
monkey model of prenatal cocaine exposure using a nonhuman primate
adaptation of the Neonatal Behavioral Assessment Scale (NBAS). Pregnant
monkeys (n=14) received 10 mg/kg cocaine twice a day orally (in fruit
treats) from the 40th through 102nd postconception days (PCD40-PCD102),
which is the period of cerebral cortical neuronogenesis ( approximately
second trimester). The control consisted of pregnant monkeys (n=14)
receiving fruit treats only. The animals were allowed to deliver vaginally
at term ( approximately PCD165). The first testing session was conducted on
PCD171 (within the first week after birth); the second testing session was
conducted on PCD177 (within the second week after birth); the third test was
conducted on PCD183 (within the third week after birth); and the fourth
testing session was conducted on PCD189 (within the fourth week after
birth). The prenatally cocaine-exposed infants showed deficits in
orientation, state control, and motor maturity, which were detectable during
the second, third, and fourth testing sessions. The same testing sessions
also revealed a significant reduction in the time devoted to toy
manipulation, which points to impaired attention. None of these
abnormalities were seen during the first testing session. The first session,
however, revealed increased tremulousness (one of the indicators of
autonomic stability) in the prenatally cocaine-exposed infants. This
impairment disappeared by the third testing session. The present findings
demonstrate the potential of prenatal cocaine exposure to induce
neurobehavioral deficits detectable by NBAS-like testing in primate infants.


the wild, cruel beast is not behind the bars of the cage. he is in front of it - axel munthe

"Never doubt that a small group of dedicated citizens can change the world. 
Indeed, it's the only thing that ever has."      Margaret Mead
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